HCID 11174145, compound → HCID 11316908, compound

HRID 353146Notes

Reaction equation

HRID 353146 reaction equation
[CH2:1]([NH:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:9][CH:10]=[N:11]2)=[CH:6][C:5]=1[N+:20]([O-:22])=[O:21])[CH3:2].[N-:23]=[C:24]=[S:25]>>[CH2:8]([NH:23][C:24]([N:17]1[CH2:18][CH2:19][N:14]([C:8]2[C:7]3[C:12](=[CH:13][C:4]([NH:3][CH2:1][CH3:2])=[C:5]([N+:20]([O-:22])=[O:21])[CH:6]=3)[N:11]=[CH:10][N:9]=2)[CH2:15][CH2:16]1)=[S:25])[C:7]1[CH:12]=[CH:13][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 11174145HCID 11174145, compoundHCID 178418790HCID 178418790, compound

Product 1

HCID 11316908HCID 11316908, compoundYield 77%

Procedure

Substantially the same procedure as in Example 60 was repeated, except that 7-ethylamino-6-nitro-4-(1-piperazinyl)quinazoline obtained in Reference Example 5 (1) was used in place of 6,7-dimethoxy-4-(1-piperazinyl)quinazoline, and the corresponding isothiocyanate was used in place of 4-phenoxyphenyl isocyanate, to give the desired compound.

Sources & evidence

ORD record
ord-6e44546592a5411795485da404688ad9
Source dataset
uspto-grants-2004_06
Patent number
US06750218B2

Reaction notes

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