1,4-Dibenzyl-2-(methoxymethyl)piperazine → 2-(Methoxymethyl)piperazine

HRID 35316Notes

Reaction equation

HRID 35316 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6][N:5]1CC1C=CC=CC=1.[H][H]>[Pd].CO>[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][NH:8][CH2:7][CH2:6][NH:5]1

Participants

5

Reactant 2

HCID 197635561,4-Dibenzyl-2-(methoxymethyl)piperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 142302642-(Methoxymethyl)piperazineYield 78.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 117 parts of 2-(methoxymethyl)-1,4-bis(phenylmethyl)piperazine and 400 parts of methanol was hydrogenated at normal pressure and at room temperature with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was distilled, yielding 38.6 parts (78.8%) of 2-(methoxymethyl)piperazine; bp. 75°-80° C. (intermediate 31).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. distillationThe residue was distilled

Sources & evidence

ORD record
ord-4954d026b551491ab7be382860feb102
Source dataset
uspto-grants-1988_08
Patent number
US04766125

Reaction notes

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