Potassium Hydroxide → HCID 10640226, compound

HRID 353176Notes

Reaction equation

HRID 353176 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.Br[C:10]([CH3:19])([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12].[OH-].[K+]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:10]([CH3:19])([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 660494-BromothiophenolHCID 90290tert-Butyl 2-bromo-2-methylpropionate

Product 1

HCID 10640226HCID 10640226, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Bromothiophenol (100 g) and tert-butyl 2-bromoisobutyrate (118 g) are dissolved in 1 l of ethanol and treated with 29 g of KOH. The mixture is stirred under reflux for 2 h and cooled, and the KBr is filtered off. The filtrate is concentrated and the residue is recrystallized from n-hexane. This gives 93.6 g of a colourless solid.

Workup

  1. temperatureunder reflux for 2 h
  2. temperaturecooled
  3. filtrationthe KBr is filtered off
  4. concentrationThe filtrate is concentrated
  5. customthe residue is recrystallized from n-hexane

Sources & evidence

ORD record
ord-d4c19ae7bff941a39a3dae7713ce0c2c
Source dataset
uspto-grants-2004_06
Patent number
US06750236B2

Reaction notes

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