Sodium Hydroxide → HCID 22708182, compound

Participants

Reaction Steps

22.01 g (51.00 mmol) of the compound from Example III-15 are stirred at 80° C. in 785 ml of ethanol in the presence of 6.12 g (153.00 mmol) of sodium hydroxide for 1 hour. The solvent is distilled off and water is added, and the mixture is then acidified using 1 N hydrochloric acid and extracted with ethyl acetate. The extract is then washed with water and saturated sodium chloride solution and dried over magnesium sulphate. The amount of solvent is reduced and the product is then filtered off with suction and dried, giving the target compound in a yield of 74%.

Provenance & Evidence