反应详情

A mixture of 9.2 parts of 2-(methoxymethyl)-4-(phenylmethyl)-1-(trifluoroacetyl)piperazine and 120 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 6.05 parts (92%) of 2-(methoxymethyl)-1-(trifluoroacetyl)piperazine as a residue (intermediate 59).

1. filtrationthe catalyst was filtered off
2. customthe filtrate was evaporated