2-(Methoxymethyl)-4-(phenylmethyl)-1-(trifluoroacetyl)piperazine → 2-(Methoxymethyl)-1-(trifluoroacetyl)piperazine

HRID 35320Notes

Reaction equation

HRID 35320 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][N:8](CC2C=CC=CC=2)[CH2:7][CH2:6][N:5]1[C:17](=[O:22])[C:18]([F:21])([F:20])[F:19].[H][H]>[Pd].CO>[CH3:1][O:2][CH2:3][CH:4]1[CH2:9][NH:8][CH2:7][CH2:6][N:5]1[C:17](=[O:22])[C:18]([F:21])([F:20])[F:19]

Participants

5

Reactant 2

HCID 212956762-(Methoxymethyl)-4-(phenylmethyl)-1-(trifluoroacetyl)piperazineHCID 178418361HCID 178418361, compound

Product 1

HCID 212957132-(Methoxymethyl)-1-(trifluoroacetyl)piperazineYield 92%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 9.2 parts of 2-(methoxymethyl)-4-(phenylmethyl)-1-(trifluoroacetyl)piperazine and 120 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 6.05 parts (92%) of 2-(methoxymethyl)-1-(trifluoroacetyl)piperazine as a residue (intermediate 59).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-626d82d2c4b54a04aa6cce4fac5598b1
Source dataset
uspto-grants-1988_08
Patent number
US04766125

Reaction notes

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