3,3-Dimethylbutanoyl chloride → HCID 69742557, compound

HRID 353275Notes

Reaction equation

HRID 353275 reaction equation
[CH2:1]([C:6](Cl)=[O:7])[C:2]([CH3:5])([CH3:4])[CH3:3].[C:9]1([C@H:15]2[NH:18][C:17](=[O:19])[C@@H:16]2[O:20][Si:21]([CH2:26][CH3:27])([CH2:24][CH3:25])[CH2:22][CH3:23])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH2:1]([C:6]([N:18]1[C@H:15]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C@@H:16]([O:20][Si:21]([CH2:26][CH3:27])([CH2:24][CH3:25])[CH2:22][CH3:23])[C:17]1=[O:19])=[O:7])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 815143,3-Dimethylbutanoyl chlorideHCID 60147326HCID 60147326, compound

Product 1

HCID 69742557HCID 69742557, compound

Procedure

By following the above procedure and using neopentylcarbonyl chloride, and (3R,4R)-4-phenyl-3-triethylsilyloxy-azetidin-2-one were converted to the title product: 1H NMR (CDCl3) δ 0.19-0.62 (m, 15H), 0.88 (s, 3H), 2.43 (d, 1H, J=13.8 Hz), 2.62 (d, 1H, J=14.1 Hz), 4.90 (d, 1H, J=5.7 Hz), 4.95 (d, 1H, J=6.0 Hz), 7.05-7.17 (m, 5H).

Sources & evidence

ORD record
ord-d97e4a9deb18404082207bb143c7ca94
Source dataset
uspto-grants-2004_06
Patent number
US06750246B1

Reaction notes

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