HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 353352Generated: October 25, 2026
Chlorotrimethylsilane → Dihydroartemisinin ethyl ether
https://huagongshe.com/reaction/353352
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Qing Hau Sau | HCID 9838675 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Dihydroartemisinin ethyl ether | HCID 72416 | 72.8% |
Reaction Steps
Artemisinin (1 g.) and polyhydroxy catalyst, dextrose (4 g.) were stirred in ethanol (15 ml). Sodium borohydride (500 mg.) was added slowly for 10 minutes and the reaction mixture was stirred for 30 minutes at room temperature (20-23° C.). After completion of the reduction step, chlorotrimethysilane (3.5 ml) was added and the reaction mixture was further stirred for 1.5 hours at room temperature. After usual work up and purification through column chromatography (1:5 ratio) a mixture of alpha and beta arteether (0.805 g., 80.5% w/w) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06750356B1 |
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| Source dataset | uspto-grants-2004_06 |
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| ORD ID | ord-291903af93754e7dade38971f634d5e8 |
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| Source note | uspto-grants-2004_06 |
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