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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 353371Generated: October 27, 2026

Sulfuric Acid → Propanamide, 2-hydroxy-2-methyl-

https://huagongshe.com/reaction/353371

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSulfuric AcidHCID 1118—
ReactantAcetone CyanohydrinHCID 6406—
ProductPropanamide, 2-hydroxy-2-methyl-HCID 83059—
ProductPropanamide, 2-hydroxy-2-methyl-, sulfate (1:1)HCID 44151542—

Reaction Steps

This preparation generally comprises the reaction of acetone cyanohydrin with concentrated sulphuric acid to give α-hydroxyisobutyramide and α-hydroxyisobutyramide sulphate. These two compounds are then heated to give sulphuric methacrylamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06750368B2
Source datasetuspto-grants-2004_06
ORD IDord-e208b1e0cb694468a30c1f4c06ed8219
Source noteuspto-grants-2004_06