HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine → 2-((Tert-butyldimethylsilyl)oxy)acetaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine | HCID 5395 | — |
| Reactant | 2-(tert-Butyl(dimethyl)silyl)oxyethanol | HCID 11137665 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-((Tert-butyldimethylsilyl)oxy)acetaldehyde | HCID 4187788 | — |
Reaction Steps
Solution 1 consisted of 108 g (0.610 mol) of 2-(tert-butyldimethylsilyloxy)ethanol and 5.8 g of 4-hydroxy-TEMPO in 400 ml of ethyl acetate. Flow rates: 48 l/h for solution 1, 30 l/h for solution 2. tert-Butyldimethylsilyloxyacetaldehyde was isolated by fractional distillation of the ethyl acetate phase. B.p.: 74-80° C. (22 mbar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06750371B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-8a6e157a737b4d039d5b66319c432844 |
| Source note | uspto-grants-2004_06 |