2,4,6-Trimethylpyridine → HCID 22644528, compound

Participants

Reaction Conditions

Reaction Steps

With reference to K-L. Yu, J. J. Bronson, H. Yang, A. Patick, M. Alam, V. Brankovan, R. Datema, M. J. M. Hitchcock, J. C. Martin, J. Med. Chem. 1992, 35, 2958-2969 0.5 mol [2-(N-hydroxyamino)-ethoxy]methylphosphonic acid diethylester and 1 mol 2,4,6-collidine in 5 ml of absolute methylenechloride are stirred under argon for one hour at a temperature of 0° C. After allowing to stand for 16 hours at room temperature the solution is concentrated in vacuum, taken up in watery acetone and stirred for 14 hours. Subsequently it is taken up in in NaOH and heated to 100° C. for 2 h. After cooling-off it is concentrated and the raw product purified by chromatography.

Provenance & Evidence