Hydrochloric Acid → HCID 178519481, compound

Participants

Reaction Steps

To a solution of 1-(5-chloroindol-2-ylsulphonyl)-4-[(2-tert-butyloxypyrimidin-4-yl)benzoyl]piperazine (200 mg, 0.361 mmol) in dichloromethane and methanol (10 ml of a 4:1 mixture) was added a solution of hydrogen chloride in methanol (0.40 ml of ˜4.5 M, 1.8 mmol), and the reaction stirred at ambient temperature for 1 hr. The solvent was removed in vacuo and the residue crystallised from ethanol to give 1-(5-chloroindol-2-ylsulphonyl)-4-[(2-hydroxypyrimidin-4-yl)benzoyl]piperazine as a colourless solid.

Provenance & Evidence