4-Nitrobenzoic Acid → HCID 12074089, compound

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Reaction Steps

To a solution of para-nitrobenzoic acid in tetrahydrofuran, 1.2 equivalents of 1,1′-carbonyldiumidazole are added and the mixture is stirred for 30 minutes. Then, 1.1 equivalents of the (S)-L-alanine tert-butyl ester are added and the mixture is stirred for 24 hours at room temperature. The solvent is removed under reduced pressure and the crude is diluted in chloroform and brine. The organic layer is washed with water and dried over MgSO4. The filtrate is concentrated under vacuum and the residue is purified by column chromatography to give the desired compound.

Provenance & Evidence