Hydroquinone → Bis(hydroxypropyl) fumarate

関与物質

反応手順

Poly(propylene fumarate) was synthesized following a two step procedure [11]. First, 1 mole of diethyl fumarate (Acros Organics, Pittsburgh, Pa.) and 3 moles of 1,2 propanediol (Acros Organics) were reacted using 0.01 moles ZnCl2 (Fisher Chemicals, Fair Lawn, N.J.) as a catalyst and 0.002 moles hydroquinone (Acros Organics) as a radical inhibitor. The reaction was run under a nitrogen blanket, producing bis(hydroxypropyl) fumarate as the main product and ethanol as a byproduct. Second, the bis(hydroxypropyl) fumarate was transesterified, producing poly(propylene fumarate) and 1,2 propanediol as a byproduct.

情報源と証拠