HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Benzylnormechlorethamine → 1-Benzyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Benzylnormechlorethamine | HCID 5928 | — |
| Reactant | Ethyl{[4-(2-butynyloxy)phenyl]sulfonyl}acetate | HCID 11335441 | — |
| Product | 1-Benzyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester | HCID 11248049 | — |
Reaction Steps
1-Benzyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-piperidine-4-carboxylic acid ethyl ester was prepared according to the general method as outlined in Example 1 (Step 6). Starting from (4-but-2-ynyloxy-benzenesulfonyl)-acetic acid ethyl ester (2 g, 6.73 mmol) and bis-(2-chloro-ethyl)-benzyl amine (2.3 g, 8.8 mmol). Yield 3.33 g (99%); yellow oil; MS: 455.9 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06753337B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-39dbae24c8d34fc2b266e4a4ef85c5ef |
| Source note | uspto-grants-2004_06 |