Ethyl{[4-(2-butynyloxy)phenyl]sulfonyl}acetate → Ethyl 4-([4-(2-butynyloxy)phenyl]sulfonyl)-1-(3-pyridinylmethyl)-4-piperidine carboxylate

Participants

Reaction Steps

Ethyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(3-pyridinylmethyl)-4-piperidine carboxylate was prepared according to the general method as outlined in example 1 (step 6), starting from (4-but-2-ynyloxy-benzenesulfonyl)-acetic acid ethyl ester (4 g, 16.9 mmol) and 3-pyridyl methyl [bis(2-chloroethyl)]amine hydrochloride (4.18 g, 18.6 mmol); 370 mg brown oil. Yield 5%; MS: 457.4 (M+H)+.

Provenance & Evidence