反应详情

To a solution of 6-(2-chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol (25.2 g, 82.9 mmol) was added a slurry of Oxone™ (105 g, 171 mmol) in 200 mL of water. The reaction mixture was stirred for 5 hours, filtered and concentrated in vacuo. The resulting slurry was filtered and the collected solids were successively washed with water four times and dried to give 23.2 g (83%) of 6-(2-chlorophenyl)-2-methanesulfonyl-pyrido[2,3-d]pyrimidin-7-ol as a light-yellow solid. Mass spec. MH+=336, mp=215.1-221.1° C.

1. filtrationfiltered
2. concentrationconcentrated in vacuo
3. filtrationThe resulting slurry was filtered
4. washthe collected solids were successively washed with water four times
5. customdried