1h-imidazole-1-carboxamide → 6-[(2,2-Diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-N-{2-[({[2-(4-isopropyl-1-Piperidinyl)ethyl]amino}carbonyl)amino]ethyl}-9H-purine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1h-imidazole-1-carboxamide	HCID 265301	—
Reactant	N-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide	HCID 11192424	—
Product	6-[(2,2-Diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-N-{2-[({[2-(4-isopropyl-1-Piperidinyl)ethyl]amino}carbonyl)amino]ethyl}-9H-purine-2-carboxamide	HCID 10169449	—

Reaction Steps

Prepared from N-(2-aminoethyl)-6-[(2,2-diphenylethyl)amino]-9-{(2R,3R,4S,5S)-5-[(ethylamino)carbonyl]-3,4-dihydroxytetrahydro-2-furanyl}-9H-purine-2-carboxamide (Preparation 10) and N-[2-4-isopropyl-1-piperidinyl)ethyl]-1H-imidazole-1-carboxamide (Preparation 22) by a similar method to Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06753322B2
Source dataset	uspto-grants-2004_06
ORD ID	ord-d074bdee4c924b838098855591617ab6
Source note	uspto-grants-2004_06