trans-10-chloro-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine → HCID 70404409, compound

HRID 35362Notes

Reaction equation

HRID 35362 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:16][CH2:15][CH2:14][C@@H:13]3[C@H:8]([O:9][CH2:10][CH2:11][NH:12]3)[C:6]=2[CH:7]=1.[C:17]([OH:24])(=[O:23])/[CH:18]=[CH:19]\[C:20]([OH:22])=[O:21].[CH3:25]N1CCO[C@@H]2C3C=CC=CC=3OCC[C@@H]12>>[C:17]([OH:24])(=[O:23])/[CH:18]=[CH:19]\[C:20]([OH:22])=[O:21].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:16][CH2:15][CH2:14][C@@H:13]3[C@H:8]([O:9][CH2:10][CH2:11][N:12]3[CH3:25])[C:6]=2[CH:7]=1

Participants

3

Reactant 2

HCID 14256324trans-10-chloro-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazineHCID 70403732HCID 70403732, compound

Product 1

HCID 70404409HCID 70404409, compound

Procedure

Following essentially the same procedure but substituting trans-10-chloro-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine for the trans-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine above, results in the formation of trans-10-chloro-3,4,4a,5,6,11b-hexahydro-4-methyl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine maleate having a mp. 142°-143° C.

Sources & evidence

ORD record
ord-6e6490f10c3f46778bf7ce042145e616
Source dataset
uspto-grants-1988_08
Patent number
US04766212

Reaction notes

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