Hydrochloric Acid → N-(2-Aminoethyl)-N'-[1-(2-pyridinyl)-4-piperidinyl]urea dihydrochloride

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Reaction Steps

To a suspension of tert-butyl 2-[({[1-(2-pyridinyl)-4-piperidinyl]amino}carbonyl)amino]ethylcarbamate (Preparation 72) (20.6 g, 0.0567 moles) in ethyl acetate (115 ml) under an atmosphere of nitrogen was added a saturated solution of hydrogen chloride in ethyl acetate (115 ml) and the resulting thick slurry was stirred at ambient temperature for 2 hours. The solid was collected by filtration and the filter cake was washed with ethyl acetate (2×50 ml) after which it was dried in vacuo at 50° C. to give the title compound (21.0 g) as a hygroscopic colourless solid, m.p. 112-120° C.

Provenance & Evidence