Benzamide → Methyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate

HRID 353660Notes

Reaction equation

Br[CH:2]([CH3:10])[C:3](=O)[CH2:4][C:5]([O:7][CH3:8])=[O:6].[C:11]([NH2:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:10][C:2]1[O:18][C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:19][C:3]=1[CH2:4][C:5]([O:7][CH3:8])=[O:6]

Participants

Reactant 2

HCID 2331Benzamide

HCID 9815681Methyl 4-bromo-3-oxopentanoate

Product 1

HCID 2775318Methyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate

Procedure

reacting methyl 4-bromo-3-oxovalerate with benzamide to give methyl 2-(5-methyl-2-phenyl-4-oxazolyl)acetate, or reacting ethyl 4-bromo-3-oxovalerate with benzamide to give ethyl 2-(5-methyl-2-phenyl-4-oxazolyl)acetate,

Sources & evidence

ORD record: ord-72b95381fdc141b28d5ab1eccdb7996b
Source dataset: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06753432B2

Reaction notes

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