Tetrahydrofuran → HCID 86742372, compound

Participants

Reaction Steps

Cis-4a,5,6,11b-tetrahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine-3(4H)-one (0.01M) was added via a solution funnel to a suspension of 0.005M lithium aluminum hydride in 100 ml of dry tetrahydrofuran. The mixture was refluxed for five hours, cooled in ice and decomposed with 15% NaOH. After stirring overnight the mixture was filtered and the solvent removed from the filtrate. The residue was dissolved in ether and treated with a solution of maleic acid in ether to give the title compound. An analytical sample was recrystallized from ethyl acetate, mp. 197°-198° C. (dec.).

Provenance & Evidence