HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → N6-(Benzyloxycarbonyl)-9-(chlorocarbonylmethyl)adenine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 9H-Purine-9-acetic acid, 6-[[(phenylmethoxy)carbonyl]amino]- | HCID 15480514 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N6-(Benzyloxycarbonyl)-9-(chlorocarbonylmethyl)adenine | HCID 22014446 | — |
Reaction Steps
Oxalyl chloride (6.3 g, 50 mmol) is added dropwise over 5 minutes to a solution of N6-(benzyloxycarbonyl)-9-(carboxymethyl)adenine (16.6 g, 50 mmol) dissolved in dichloromethane (200 mL). The reaction is stirred until gas evolution has ceased and then for an additional 2 hours. The reaction mixture is evaporated to an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06756199B1 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-6ab82f6a965c4e4ebdab6ea898398bbd |
| Source note | uspto-grants-2004_06 |