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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 353754Generated: October 25, 2026

Cyanamide → {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanone

https://huagongshe.com/reaction/353754

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyanamideHCID 9864—
ReactantBromomethyl 3-methoxyphenyl ketoneHCID 101294—
Reactant1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazineHCID 21958916—
Product{4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-methoxy-phenyl)-methanoneHCID 21958932—

Reaction Steps

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine (of Example 14G) and 2-bromo-1-(3-methoxyphenyl)ethanone (Aldrich) following the procedure used in Example 24 Mass spectrum (ES) MH+=464.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06756374B2
Source datasetuspto-grants-2004_06
ORD IDord-cfbca6b335584712acd3fb0b27e7e138
Source noteuspto-grants-2004_06