Cyanamide → {4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-benzo[1,3]dioxol-5-yl-methanone

Participants

Role	Name	HCID	Charge
Reactant	Cyanamide	HCID 9864	—
Reactant	1-(1,3-Dioxaindan-5-yl)-2-bromoethan-1-one	HCID 243777	—
Reactant	1-(4-Isothiocyanatophenyl)-4-cyclopropylmethylpiperazine	HCID 21958916	—
Product	{4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-benzo[1,3]dioxol-5-yl-methanone	HCID 10277319	—

Reaction Steps

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine (of Example 14G) and 2-bromo-1-(benzo[1,3]dioxol-5-yl)ethanone (of Example 11) following the procedure used in Example 24 Mass spectrum (ES) MH+=478.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06756374B2
Source dataset	uspto-grants-2004_06
ORD ID	ord-c603d27329694bfab3d48aecf27a493f
Source note	uspto-grants-2004_06