反应详情

温度

50 °C

To a solution of 4-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)pentanoic acid methyl ester (1 eq) in ethanol was added sodium borohydride (4 eq) at room temperature. The reaction mixture was heated in a 50° C. oil bath for 60 minutes and then quenched by addition of H2O. Once the reaction solvent was removed in vacuo, a solution of the residue in dichloromethane was washed with NaCl(sat), dried over sodium sulfate, filtered and concentrated to give 4-Methyl-4-(4-pyridin-3-yl-imidazol-1-yl)-pentan-1-ol (68%). MH+(246).

1. customquenched by addition of H2O
2. customOnce the reaction solvent was removed in vacuo
3. washa solution of the residue in dichloromethane was washed with NaCl(sat)
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated