1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine → n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide

Participants

Role	Name	HCID	Charge
Reactant	1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine	HCID 23512719	—
Reactant	N-Hydroxysuccinimido-d-biotin	HCID 129676281	—
Product	n1-[2-(4-Amino-1h-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide	HCID 23512652	75.2%

Reaction Steps

Using the general method of Example 24, N-hydroxysuccinimidobiotin (0.6 g, 1.76 mmol) was reacted with 1-(2-aminoethyl)-1H-imidazo[4,5-c]quinolin-4-amine (0.4 g, 1.76 mmol) to provide 0.6 g of N1-[2-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)ethyl]-5-(2-oxoperhydrothieno[3,4-d]imidazol-4-yl)pentanamide as a solid, m.p. 169° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06756382B2
Source dataset	uspto-grants-2004_06
ORD ID	ord-f709e896713b43d192213f490d1d6cec
Source note	uspto-grants-2004_06