Quinoline-3-carboxylic acid → N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}quinoline-3-carboxamide

Participants

Reaction Steps

Using the general method of Example 181 1-(4-aminobutyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (2.0 g, 6.37 mmol) was reacted with quinoline-3-carboxylic acid (1.33 g, 7.66 mmol) to provide 850 mg of N-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}quinoline-3-carboxamide as a yellow solid, m.p. 114-116° C. Analysis: Calculated for C27H28N6O2.0.2 H2O: % C, 68.68; % H, 6.06; % N, 17.80. Found: % C, 68.68; % H, 5.85; % N, 17.76.

Provenance & Evidence