化工社化工社 化学情報印刷レポート · 研究参考用
Chlorosulfonic acid → 5-tert-Butyl-2-methoxybenzene-1-sulfonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorosulfonic acid | HCID 24638 | — |
| 反応物 | p-tert-Butylanisole | HCID 94750 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-tert-Butyl-2-methoxybenzene-1-sulfonyl chloride | HCID 13210231 | — |
反応手順
12.3 g (0.075 mole) of 4-(1,1-dimethylethyl)anisole, dissolved in 30 ml of methylene chloride, are added dropwise, while cooling with ice, to 16.5 ml of chlorosulfonic acid, dissolved in 20 ml of methylene chloride. The mixture is stirred for 40 minutes and is then poured into ice water. The organic phase is separated off, washed with water, dried with MgSO4 and concentrated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766241 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c7305427180c47d1a6c40d91e5bf8adc |
| 出典メモ | uspto-grants-1988_08 |