HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Morpholine-4-carboxylic acid {1-[4-cyano-1-(4-methyl-piperazine-1-carbonyl)-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-Methyl-1-piperazinecarbonyl chloride | HCID 3016935 | — |
| Reactant | Morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride | HCID 22260409 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Morpholine-4-carboxylic acid {1-[4-cyano-1-(4-methyl-piperazine-1-carbonyl)-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide | HCID 131724467 | — |
Reaction Steps
The title compound is prepared from morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride and 4-methyl-piperzine carbonyl chloride in the presence of a tertiary amine base such as N-methylmorpholine in a solvent such as methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06756372B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-05c12bb62f8741ff9290de62cab4ab5e |
| Source note | uspto-grants-2004_06 |