HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobutyric acid → 4-(4-Cyano-4-{3-cyclohexyl-2-[(morpholine-4-carbonyl)-amino]-propionylamino}-piperidin-1-yl)-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobutyric acid | HCID 75809 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride | HCID 22260409 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-Cyano-4-{3-cyclohexyl-2-[(morpholine-4-carbonyl)-amino]-propionylamino}-piperidin-1-yl)-butyric acid | HCID 22063115 | — |
Reaction Steps
The title compound is prepared from morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride and 4-bromo-butyric acid in the presence of a hindered tertiary amine base such as Hunig's base in a solvent such as methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06756372B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-5b32688c65c34c678a6d9d5c8dd22a81 |
| Source note | uspto-grants-2004_06 |