Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Amlodipine | HCID 2162 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 246852-07-3 | HCID 22228524 | — |
Reaction Steps
To 100 ml of methanol was added 12 ml of conc-hydrochloric acid. A solution of 54 g of amlodipine prepared in Reference Example 1 in 500 ml of methanol was added dropwise, followed by stirring at 23° C. for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06756390B2 |
|---|
| Source dataset | uspto-grants-2004_06 |
|---|
| ORD ID | ord-f61a6f18e1e346c8a7a7fb9943707569 |
|---|
| Source note | uspto-grants-2004_06 |
|---|
