Amlodipine → Amlodipine (S)-Tetrahydro-5-oxo-2-furancarboxylate

Participants

Reaction Steps

Amlodipine (10 g, 0.025 mole) was dissolved in ethyl acetate (100 ml) with stirring. The solution was adjusted to 3° C. and slowly added with (S)-tetrahydro-5-oxo-2-furancarboxylic acid (3.69 g, 0.028 mole) prepared according to Korean Pat. Publication No. 0159540 to obtain a clear solution. This reaction was stirred at 3° C. for 20 hour to produce precipitates. They were filtered off and washed with ethyl acetate (50 ml), followed by drying at 40° C. under vacuum to give 12.4 g of the title compound (Yield 92.0%).

Provenance & Evidence