Amlodipine besylate → Amlodipine tetrahydro-5-oxo-2-furancarboxylate

HRID 353987Notes

Reaction equation

HRID 353987 reaction equation
[O:1]=[C:2]1[O:6][CH:5]([C:7]([O-:9])=[O:8])[CH2:4][CH2:3]1.[CH3:10][CH2:11][O:12][C:13]([C:15]1[CH:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=2[Cl:27])[C:19]([C:28]([O:30][CH3:31])=[O:29])=[C:18]([CH3:32])[NH:17][C:16]=1[CH2:33][O:34][CH2:35][CH2:36][NH2:37])=[O:14].C1C=CC(S(O)(=O)=O)=CC=1>O>[CH3:10][CH2:11][O:12][C:13]([C:15]1[CH:20]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=2[Cl:27])[C:19]([C:28]([O:30][CH3:31])=[O:29])=[C:18]([CH3:32])[NH:17][C:16]=1[CH2:33][O:34][CH2:35][CH2:36][NH2:37])=[O:14].[O:1]=[C:2]1[O:6][CH:5]([C:7]([O-:9])=[O:8])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 60496Amlodipine besylateHCID 21920443HCID 21920443, compound

Product 1

HCID 131724468Amlodipine tetrahydro-5-oxo-2-furancarboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To investigate the stability in an aqueous state, mlodipine tetrahydro-5-oxo-2-furancarboxylate prepared in Example 3 and amlodipine besylate prepared in Reference Example 1 were separately dissolved in distilled water. The resulting aqueous solutions were stored at 25° C. for 4 weeks in the dark, after which a measurement was made of the contents of the salts with resort to HPLC under the same conditions as in the solid state.

Workup

  1. customprepared in Reference Example 1
  2. waitThe resulting aqueous solutions were stored at 25° C. for 4 weeks

Sources & evidence

ORD record
ord-fb5f80a571a54e17a6f125e356931306
Source dataset
uspto-grants-2004_06
Patent number
US06756390B2

Reaction notes

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