反应详情

To investigate the stability in an aqueous state, mlodipine tetrahydro-5-oxo-2-furancarboxylate prepared in Example 3 and amlodipine besylate prepared in Reference Example 1 were separately dissolved in distilled water. The resulting aqueous solutions were stored at 25° C. for 4 weeks in the dark, after which a measurement was made of the contents of the salts with resort to HPLC under the same conditions as in the solid state.

1. customprepared in Reference Example 1
2. waitThe resulting aqueous solutions were stored at 25° C. for 4 weeks