Hydrochloric Acid → HCID 178482845, compound

Participants

Reaction Steps

To a solution of 0.3 g (0.58 mmol) 2-methanesulfonyl-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 10 ml dioxan/H2O 5 ml 2N NaOH solution was added. The reaction mixture was stirred for 3 hrs. The pH of the reaction solution was than adjusted to 4 with 25% HCl. The aqueous layer was extracted three times with 50 ml CH2Cl2, the combined organic layers dried (MgSO4), filtered and evaporated. The residue was purified by chromatography (SiO2, CH2Cl2/methanol 9:1) to give 0.20 g (75%) 2-hydroxy-5-phenyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a off-white solid, m.p. 218.5-219.5°.

Provenance & Evidence