Hydrochloric Acid → HCID 23512576, compound

Participants

Reaction Steps

To a solution of 3.00 g (9.72 mmol) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester in 15 ml ethanol a solution of 0.58 g (14.5 mmol) NaOH in 15 ml was added at RT and the reaction solution was stirred for 1 hr. The pH of the solution was than adjusted to 1 by addition of 25% HCl. The resulting solution was extracted twice with 100 ml CH2Cl2/methanol (2:1). The combined organic phases were dried (MgSO4), filtered and evaporated. The residue was suspended in 20 ml diisopropylether, filtered and dried to give 2.40 g (88%) 5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidine-4-carboxylic acid as an off-white solid.

Provenance & Evidence