1,4-Dioxane → HCID 11180626, compound

HRID 354002Notes

Reaction equation

HRID 354002 reaction equation
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]([CH3:27])[C:8]([C:10]1[C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[CH:14][N:13]=[C:12](S(C)(=O)=O)[N:11]=1)=[O:9].O1[CH2:42][CH2:41]OCC1>>[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]([CH3:27])[C:8]([C:10]1[C:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[CH:14][N:13]=[C:12]([N:11]2[CH2:42][CH2:41][N:7]([CH3:6])[CH2:8][CH2:10]2)[N:11]=1)=[O:9]

Participants

3

Reactant 2

HCID 312751,4-DioxaneHCID 11341866HCID 11341866, compound

Product 1

HCID 11180626HCID 11180626, compoundYield 179.7%

Procedure

To a solution of 0.40 g (0.72 mmol) 5-(2-chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide in 10 ml dioxan 0.20 ml (1.81 mmol) 1-methyl-piperazine was added. The reaction mixture was stirred for 16 hrs. After evaporation of the solvent, the residue was distributed between 50 ml CH2Cl2 and 50 ml H2O. The aqueous layer was extracted with 50 ml CH2Cl2, the combined organic layers dried (MgSO4), filtered and evaporated. The residue was purified by chromatography (SiO2, CH2Cl2/MeOH/NH4OH 110:10:1) to give 0.37 g (89%) 5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide as a white foam, MS (ISP): 572.1 (M+H+).

Workup

  1. customAfter evaporation of the solvent
  2. extractionThe aqueous layer was extracted with 50 ml CH2Cl2
  3. dry with materialthe combined organic layers dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was purified by chromatography (SiO2, CH2Cl2/MeOH/NH4OH 110:10:1)

Sources & evidence

ORD record
ord-673a407472d44d9d966fb3e98cfbebdf
Source dataset
uspto-grants-2004_06
Patent number
US06756380B1

Reaction notes

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