참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tributyltin Chloride | HCID 15096 | — |
| 반응물 | Lithium cyclohexylisopropylamide | HCID 10877271 | — |
| 반응물 | Phosphonic acid, 2-furanyl-, diethyl ester | HCID 12485182 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Diethyl 5-tributylstannyl-2-furanphosphonate | HCID 22280515 | — |
반응 단계
A solution of diethyl 2-furanphosphonate (1 mmole, prepared as in Step C of Example 1) in THF was cooled at −78° C. and cannulated to a solution of lithium N-isopropyl-N-cyclohexylamide in THF at −78° C. over 15 min. The resulting mixture was stirred at −78° C. for 2 h and cannulated into a solution of tributyltin chloride (1 mmole) in THF at −78° C. over 20 min. The mixture was then stirred at −78° C. for 1 h, and at 25° C. for 12 h. Extraction and chromatography gave compound (14) as a light yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06756360B1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_06 |
|---|
| ORD ID | ord-ac6d7a8faf9d4c838dfacd28699a9e3f |
|---|
| 출처 메모 | uspto-grants-2004_06 |
|---|
