Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 354034Generated: October 29, 2026

1,3-Dihydro-3-oxo-1-isobenzofuranacetic acid → 2-(3-Phthalidyl)ethanol

https://huagongshe.com/reaction/354034

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Dihydro-3-oxo-1-isobenzofuranacetic acidHCID 589730—
Reactant(Dimethyl sulfide)trihydroboronHCID 12423031—
SolventTetrahydrofuranHCID 8028—
Product2-(3-Phthalidyl)ethanolHCID 22274970—

Reaction Steps

A solution of phthalide-3-acetic acid (1 mmole) in THF was treated with borane dimethylsulfide (1.5 mmole) at 0° C. for 1 h, and at 25° C. for 24 h. Extraction and chromatography gave 2-(3-phthalidyl)ethanol as a light yellow oil: Rf=0.25, 50% EtOAc-hexane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06756360B1
Source datasetuspto-grants-2004_06
ORD IDord-6bae3aeb86a0405893a7918e73544310
Source noteuspto-grants-2004_06