Piconol → HCID 12992509, compound

Participants

Reaction Steps

The coupling of the product from Step 2, Example 10 (Methanesulfonic acid 4-[3-(4-hydroxy-benzoyl)-6-methanesulfonyloxy-benzo[b]thiophen-2-yl]-phenyl ester) and pyridin-2-yl-methanol was accomplished by using the procedure outlined in Example 10, Step 3 except stirring for 1 hour instead of 16 hours at room temperature. The solvent was evaporated off and the crude product was chromatographed on silica gel using 1% MeOH/methylene chloride to 2% MeOH/methylene chloride as the gradient eluant to yield the title compound.

Provenance & Evidence