反应详情

To a suspension of 6-methoxy-2-(4-methoxyphenyl) -benzo[b]thiophene (2 g, 7.4 mmol), and ρ-anisoyl chloride in 110 mL of methylene chloride was added aluminum trichloride (4.93 g, 37 mmol) in three portions and the reaction was stirred overnight. It was then quenched with 200 mL of 2N sodium hydroxide and extracted with methylene chloride. The combined organic layers was washed with brine and dried over anhydrous magnesium sulfate. After filtration, concentration and silica gel column chromatography using 15% ethyl acetate—hexanes as eluant the title compound (1.73 g) was obtained.

1. customIt was then quenched with 200 mL of 2N sodium hydroxide
2. extractionextracted with methylene chloride
3. washThe combined organic layers was washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationAfter filtration, concentration and silica gel column chromatography
6. customwas obtained