4-Iodobenzoyl chloride → HCID 23512917, compound

Participants

Reaction Steps

To a suspension of 6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene 25 (3 g, 11.1 mmol), and ρ-iodobenzoyl chloride in 65 mL of methylene chloride was added aluminum trichloride (2.1 g) in three portions and the reaction was stirred 3 hours. It was then poured into ice-water and extracted with methylene chloride. The combined organic layers was washed with brine and dried over anhydrous magnesium sulfate. After filtration, concentration and silica gel column chromatography with 3% ethyl acetate-hexanes as eluant the title compound (3.97 g) was obtained.

Provenance & Evidence