Boron tribromide → HCID 12992346, compound

Participants

Reaction Conditions

Reaction Steps

The product from Step 4 (120 mg, 0.24 mmol) was dissolved in methylene chloride (0.5 mL), cooled to 0° C. and treated with boron tribromide (1.2 mL, 1 M, 1.2 mmol) and stirred for 30 minutes. The reaction was quenched with saturated sodium bicarbonate solution and extracted intochloroform. The combined organic layers was dried over anhydrous magnesium sulfate. After filtration, concentration and silica gel column chromatography with 2% methanol-methylene chloride as eluant the title compound (24 mg) was obtained.

Provenance & Evidence