HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 5-Indanol | HCID 15118 | — |
| Reactant | N-Methylol-alpha-chloroacetamide | HCID 62466 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide | HCID 21296915 | — |
Reaction Steps
134 g (1 mole) of 5-hydroxyindane and 100 g (0.81 mole) of 2-chloro-N-hydroxymethylacetamide are suspended in 300 ml of glacial acetic acid, and 10 ml of concentrated sulfuric acid are added. The mixture is stirred for 30 minutes at room temperature and is poured into ice water. The product is filtered off with suction and recrystallized from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766241 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-9f24ddb28e444a7a9f35cd26d6f49873 |
| Source note | uspto-grants-1988_08 |