Chlorosulfonic acid → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

HRID 35413Notes

Reaction equation

HRID 35413 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[CH:9][C:8]=1[OH:16])=[O:4].[Cl:17][S:18](O)(=[O:20])=[O:19]>>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:18]([Cl:17])(=[O:20])=[O:19])[C:8]=1[OH:16])=[O:4]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

Product 1

HCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

Procedure

70 g (0.29 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxyindane are dissolved in 150 ml of chlorosulfonic acid, and the mixture is stirred for approx. 30 minutes at room temperature. The mixture is poured into ice water and the product is filtered off with suction. The initially crystalline material becomes oily after a little time and is employed in the next stage in this form without further purification.

Workup

  1. filtrationthe product is filtered off with suction
  2. customis employed in the next stage in this form without further purification

Sources & evidence

ORD record
ord-602c8eb7a33141f29baf3356b4e49d0a
Source dataset
uspto-grants-1988_08
Patent number
US04766241

Reaction notes

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