5-ethyl-1-(2-methoxyethyl)-4-nitro-1H-pyrazole-3-carboxamide → 4-amino-5-ethyl-1-(2-methoxyethyl)-1H-Pyrazole-3-carboxamide

Participants

Reaction Steps

10% Palladium on carbon (100 mg) was added to a stirred slurry of 3-ethyl-2-(2-methoxyethyl)-4-nitro-pyrazole-5-carboxamide (5 g, 20.77 mmol) in ethanol (100 mL) and the mixture stirred in a pressure vessel under a hydrogen atmosphere (344.7 kPa (50 psi)) at room temperature for 6 h. The mixture was filtered and concentrated. Recrystallisation from hot ethyl acetate gave the product as white crystals (3.5 g). The mother liquor was concentrated to give a further 1.5 g of product as a grey powder.

Provenance & Evidence