Hydrochloric Acid → HCID 135730603, compound

Participants

Reaction Steps

Sodium hydroxide (0.52 mL of 2N) was added to a solution of methyl 6-butoxy-5-[3-ethyl-2-(2-methoxyethyl)-7-oxo-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-5-yl]nicotinate (Example 2) (226 mg, 0.53 mmol) in dioxane. The solution was stirred for 14 h. The pH was adjusted to pH 2-3 with hydrochloric acid (1N) and the mixture concentrated to dryness. Hot ethanol was added to the solid and the slurry filtered. The ethanol solution was concentrated and the resulting solid was washed with dichloromethane resulting in the title compound (156 mg, 72%).

Provenance & Evidence