Chloroacetone → HCID 136388376, compound

Participants

Reaction Steps

6-Isobutoxy-5-(2-methyl-7-oxo-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]-pyrimidin-5-yl)-3-pyridinecarbothioamide (Example 37) (77 mg, 0.19 mmol) and chloroacetone (36 mg, 0.38 mmol) were heated to reflux for 14 h in ethanol (5 mL). The reaction mixture was cooled and concentrated. Purification by flash column chromatography (gradient elution from 100% dichloromethane to 3% methanol:dichloromethane) gave 65 mg of product.

Provenance & Evidence