Potassium Hydroxide → HCID 135494405, compound

Participants

Reaction Steps

The title compound of Example 76 (56 mg, 0.1 mmol) was dissolved in propanol (1.4 mL) and aq. KOH solution (1 M, 0.14 mL) and the mixture heated to 45° C. for 2.5 h. The reaction mixture was concentrated in vacuo and the residue diluted with water (2 mL) and acidified to pH 2-3 with conc. hydrochloric acid to afford a precipitate which was removed by filtration, washed with water and diethyl ether before drying to give the title compound as an off-white solid (26 mg, 0.06 mmol).

Provenance & Evidence