Sodium Hydroxide → HCID 135730616, compound

HRID 354199Notes

Reaction equation

HRID 354199 reaction equation
[OH-].[Na+].[CH3:3][N:4]1[C:12]2[C:11](=[O:13])[NH:10][C:9]([C:14]3[CH:15]=[C:16]([NH:24][C:25](=[O:31])[CH2:26][C:27]([O:29]C)=[O:28])[CH:17]=[N:18][C:19]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:8][C:7]=2[C:6]([CH2:32][CH2:33][CH3:34])=[N:5]1>CO>[CH3:3][N:4]1[C:12]2[C:11](=[O:13])[NH:10][C:9]([C:14]3[CH:15]=[C:16]([NH:24][C:25](=[O:31])[CH2:26][C:27]([OH:29])=[O:28])[CH:17]=[N:18][C:19]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:8][C:7]=2[C:6]([CH2:32][CH2:33][CH3:34])=[N:5]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135730642HCID 135730642, compound

Product 1

HCID 135730616HCID 135730616, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium hydroxide (2 N, aq., 1 mL) was added to a solution of the title compound of Example 78 (79 mg, 0.18 mmol) in methanol (10 mL) and the resultant mixture stirred at room temperature for 19 h, concentrated in vacuo and the residue dissolved in water (20 mL). After washing with dichloromethane (20 mL), the aqueous phase was acidified to pH 2-3 with 2 M HCl and the resultant white precipitate removed by filtration and dried to afford the title compound (58 mg, 0.14 mmol).

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutionthe residue dissolved in water (20 mL)
  3. washAfter washing with dichloromethane (20 mL)
  4. customthe resultant white precipitate removed by filtration
  5. customdried

Sources & evidence

ORD record
ord-992114fb11014548ba7425c17389279c
Source dataset
uspto-grants-2004_06
Patent number
US06756373B1

Reaction notes

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