Trifluoroacetic acid → HCID 135520500, compound

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Reaction Steps

Trifluoroacetic acid (7 ml, 40%vol) was added to a solution of the title compound of example 129 in dry Methylene chloride (10 ml), and the mixture was stirred at room temperature under nitrogen for 45 mins. The mixture was concentrated in vacuo and the residue partitioned between NaHCO3 (sat. aq., 50 ml) and Methylene chloride (100 ml). The organic layer was separated (emulsion) and washed with water (50 ml). Organic layer was removed, and the aqueous extracted with Methylene chloride (2×50 ml). The combined organics were dried (MgSO4), and concentrated in vacuo. The crude product was purified by column chromatography (95:5:0.5 methylene chloride:methanol:0.88 NH3 as eluent) to yield the title compound (containing trace impurity; carried through crude to next step).

Provenance & Evidence